The research clearly shows that naloxone is not effective in any route of administration when combined with buprenorphine. Even those who choose to use their medication intravenously will Almost Never become ill with withdrawal symptoms. Buprenorphine itself has a much stronger binding affinity to opiate receptors and last several times as long as naloxone meaning that the buprenorphine we'll find stronger and longer to receptors then the naloxone ever could. It is truly useless in the presence of buprenorphine. So there is no reason two insist that that formulation is best. All it is is way more expensive. The buprenorphine alone will block a patient from being able to use other full Agonist opiates and achieve a high. Then the lock Zone does absolutely nothing and is a waste of time money and resources. This is very simple science that can be confirmed on any reputable website or other source. It is widely misunderstood but it is the scientific truth. Please don't make those in recovery suffer because of false information. Thank you